| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10971727 | Developmental & Comparative Immunology | 2012 | 8 Pages |
Abstract
⺠This paper characterizes SHM patterns in shark TCR γ chains. ⺠We identify shark hotspot motifs identical to those of mammals. ⺠Mechanism of SHM in shark B cells and T cells are very similar. ⺠Point mutations in sharks and mammals are generated by similar mechanisms. ⺠We propose a model for the generation of tandem mutations found only in shark SHM.
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Authors
Hao Chen, Harris Bernstein, Parvathi Ranganathan, Samuel F. Schluter,