| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10971729 | Developmental & Comparative Immunology | 2012 | 9 Pages |
Abstract
⺠The role of FOXO transcription factors in innate immunity is tested with C. elegans. ⺠C. elegans FOXO DAF-16 is directly activated by pathogenic Bacillus thuringiensis. ⺠DAF-16 activation mainly depends on pathogenicity but not infection load alone. ⺠Increased DAF-16 levels associate with increased host defence. ⺠FOXO transcription factors can thus be part of a direct immune response to pathogens.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Developmental Biology
Authors
Jun Wang, Rania Nakad, Hinrich Schulenburg,