Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10972639 | International Journal for Parasitology | 2012 | 6 Pages |
Abstract
⺠We sought to conditionally silence the chloroquine resistance transporter to test its role across the Plasmodium lifecycle. ⺠This used the Flp/FRT system to excise the 3'UTR during mosquito passage, leading to unstable, non-functional transcripts. ⺠Despite successful excision, Plasmodium berghei progressed normally through the lifecycle by attaching alternative 3'UTR elements. ⺠This study highlights the remarkable ability of Plasmodium at the genomic level, to overcome disruption of essential genes.
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Authors
Andrea Ecker, Rebecca E. Lewis, Eric H. Ekland, Bamini Jayabalasingham, David A. Fidock,