Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10972681 | International Journal for Parasitology | 2011 | 10 Pages |
Abstract
⺠The monoclonal antibody against the C-terminal end of the Trypanosoma cruzi ribosomal P2 protein (R13 peptide), called mAb 17.2, and its single chain Fv fragment (scFv) C5, cause apoptosis of murine adult cardiac HL-1 cells. ⺠This effect is due to antibody interaction with cardiac β-adrenergic receptors. ⺠Antibodies developed in chronic Chagas heart disease (cChHD) patients with high reactivity against T. cruzi lysate and R13 peptide. ⺠Antibodies also induce programmed cardiac cell death, by a mechanism that partially involves cross-reactivity of the C-terminal end of ribosomal P proteins and the β-adrenergic receptors.
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Authors
Gabriela V. Levy, Laura M. Tasso, Silvia A. Longhi, Hernán GarcÃa Rivello, Ville Kytö, Pekka Saukko, Mariano J. Levin, Karina A. Gómez,