Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10972699 | International Journal for Parasitology | 2011 | 7 Pages |
Abstract
⺠First reported time course of cytokine mRNA expression in the local tissue of the same animal after infection with a gastrointestinal nematode showing different levels of induction correlating with different life cycle changes. ⺠Decrease of cytokine expression during chronic adult infection. ⺠First kinetics of galectin-14 and galectin-11 mRNA and protein expression after helminth infection. ⺠Significant negative correlation between galectin-14 protein at day 2 post challenge and final adult worm burden, confirming that eosinophil killing of infective L3s may be the major mechanism of immunity in this system. ⺠Dramatic induction of galectin-11 protein and mRNA expression may correlate with mucus changes and prevention of re-infection.
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Authors
Nicholas Robinson, Jill Pleasance, David Piedrafita, Els N. Meeusen,