| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10972725 | International Journal for Parasitology | 2011 | 7 Pages |
Abstract
⺠A pyrimethamine+sulphadoxine-resistant rodent malaria genome was sequenced. ⺠Its genome sequence was compared with that of a sensitive progenitor. ⺠Four point mutations were identified: on chromosomes 2, 7, 13 and 14. ⺠The K392Q mutation in mdr2 is genetically linked to sulphadoxine resistance. ⺠mdr2 is a novel candidate gene underlying antifolate resistance in malaria.
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Immunology and Microbiology
Parasitology
Authors
Axel Martinelli, Gisela Henriques, Pedro Cravo, Paul Hunt,