Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10972846 | International Journal for Parasitology | 2010 | 5 Pages |
Abstract
Infection of C3HeB/FeJ and C57BL/6 mice with Leishmania major stimulates a healing cell-mediated immune response, while Leishmania amazonensis infection leads to chronic disease. Here we show C3HeB/FeJ mice co-infected with both species of Leishmania heal, while co-infected C57BL/6 mice do not. Using an in vitro killing assay we determined B cells from infected C57BL/6 mice are ineffective in promoting parasite killing compared with B cells from infected C3HeB/FeJ mice. Furthermore, infected C57BL/6 mice produce less antigen-specific antibodies compared with infected C3HeB/FeJ mice. These findings suggest B cells play a required role in the cell-mediated immune response against L. amazonensis.
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Authors
Katherine N. Gibson-Corley, Paola M. Boggiatto, Rami M. Mukbel, Christine A. Petersen, Douglas E. Jones,