Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10972919 | International Journal for Parasitology | 2007 | 10 Pages |
Abstract
Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.
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Authors
Martin Wiese,