Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10998216 | Science Bulletin | 2015 | 6 Pages |
Abstract
A copper-catalyzed highly stereoselective cyclopropanation of 1,2-disubstituted olefins with α-nitro-diazo acetates has been developed, giving the desired products in up to 97% yields, up to >99/1 dr and up to 98% ee, which provides an efficient access to the synthesis of optical active cyclopropane α-amino acids and unnatural α-amino acid derivatives.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Liang-Wen Feng, Peng Wang, Lijia Wang, Yong Tang,