Investigation of B-F substitution on BODIPY and aza-BODIPY dyes: Development of B-O and B-C BODIPYs

Among the wide-range of chemical reactions that can be performed on BODIPYs, attack on the boron atom opens the door to the synthesis of numerous more or less complex fluorophores. Moreover, the modifications that occur preserve the unique photo-physical properties of while improving their quantum yield, stability and solubility either in water or in organic solvents. This field has been far less investigated to date than dipyrrin core derivatization has. The aim of this work is to provide a comprehensive review of the different synthetic methodologies reported for the introduction of alkyl or alcohol substituents on the boron of BODIPYs.