Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11000661 | The Journal of Chemical Thermodynamics | 2019 | 5 Pages |
Abstract
The enthalpies of dilution of mixed aqueous solutions of glycine (Gly, x) or l-alanine (Ala, x) with mebicar (Meb, y), a well-known pharmaceutical, were measured calorimetrically at 298.15â¯K. The enthalpic heterotactic coefficients for pair, hxy, and triplet, hxxy and hxyy, interactions between hydrated solute molecules were estimated using the McMillan-Mayer formalism. Similar to the homotactic parameters hxx and hyy, the hxy value for the ternary (waterâ¯+â¯Glyâ¯+â¯Meb) system was found to be negative in sign. It points to the predomination of zwitterion (hydrophilic) - hydrophilic interactions in this mixed solution. In the case of the (waterâ¯+â¯Alaâ¯+â¯Meb) system, hxxâ¯>â¯0 and hxyâ¯>â¯0, a fact testifying to the prevailingly hydrophobic character of the Ala - Meb interaction in the aqueous medium.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Chemical Engineering (General)
Authors
Evgeniy V. Ivanov, Dmitriy V. Batov,