| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 11002010 | Neurobiology of Aging | 2018 | 9 Pages |
Abstract
It has been reported that DNA repair pathways could modify age at onset (AO) in Huntington disease (HD) and spinocerebellar ataxias. We genotyped 22 SNPs from DNA repair pathways in a large cohort of 798 Chinese Machado-Joseph disease patients to investigate the association with AO, and no significant finding was observed. Our findings did not provide a strong evidence for the modulatory effect of DNA repair pathways on the AO of Chinese Machado-Joseph disease patients. Further analyses with more representative DNA repair-related SNPs in different populations are needed to identify new potential genetic modifiers.
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Ageing
Authors
Chunrong Wang, Zhao Chen, Huirong Peng, Yun Peng, Xin Zhou, Huihua Yang, Puzhi Wang, Tianjiao Li, Xiaocan Hou, Rong Qiu, Kun Xia, Jorge Sequeiros, Beisha Tang, Hong Jiang,