Chronic stress prior to hippocampal stroke enhances post-stroke spatial deficits in the ziggurat task

► Stress history impaired the hippocampal function in the ziggurat task after stroke. ► Pre-stroke stress also induced enhanced tissue loss in the hippocampus. ► These effects have not been found with treatment with corticosterone alone. ► Dorsal and ventral hippocampus may respond differently to stress experiences.