Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11005763 | Microchemical Journal | 2018 | 45 Pages |
Abstract
Determining of acidic, basic and amphiprotic drugs from different samples simultaneously is a remarkable and discussible topic in sample preparation methods. In this work, an easy and fast dispersive micro-solid phase extraction (D-μ-SPE) method was developed using a magnetic multiwalled carbon nanotubes/Fe3O4@poly(2âaminopyrimidine) (MWCNTs/Fe3O4@PAPy) as a viable and efficient sorbent to preconcentrate and determine five model analytes in three different classes (nortriptyline, cetirizine, naproxen, diclofenac and ibuprofen). The nanosorbent was characterized by diverse characterization techniques. After the extraction step, HPLC-photo diode array detection (HPLC-DAD) was employed to quantify the model analytes. The effects of various parameters on the dispersive magnetic solid phase extraction method were explored thoroughly via design of experiment and desirability function. The highest extraction performance was obtained under the conditions of: a sample pH of 2, a sorbent amount of 8â¯mg, a sorption time of 5â¯min, a salt concentration of 20% w/v in the sample solution, 120â¯Î¼L 0.01â¯molâ¯Lâ1 HCl in acetonitrile as an eluent, and an elution time of 2â¯min. By employing the optimum conditions detection limits and linear dynamic ranges were obtained in the range of 0.07-3.5â¯Î¼gâ¯Lâ1 and 0.25-1500â¯Î¼gâ¯Lâ1, respectively. The relative standard deviations (nâ¯=â¯5) were between 1.4% and 10.5%. Eventually, this method was simply applied for determination and extraction of target analytes in different samples.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Niloofar Jalilian, Homeira Ebrahimzadeh, Ali Akbar Asgharinezhad,