| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 11006706 | Materials Science and Engineering: C | 2018 | 14 Pages |
Abstract
Thus, this review aims to compile the recent innovations of inhalable polymeric dry powder systems for the delivery of anti-TB drugs exploring the methods of production, aerodynamic characterization and the efficacy of targeted drug delivery systems using in vitro and in vivo models of the disease. Advanced knowledge and promising outcomes of these systems are anticipated to simplify and revolutionize the pulmonary drug delivery and to contribute towards more effective anti-TB treatments.
Keywords
SPGPCLTPPRPTEToCHIPLAMICALGSASSLFECMMDR-TBXDR-TBMTBSCO2RBTEthionamideDPIsLBGShirasu porous glassOFXHPMCPBSPLGAPolylactideIL-6MMADFPFMNPsExtensively drug-resistant tuberculosisLocust bean gumAlginateethambutolEthyl celluloseHyaluronic acidPara-aminosalicylic acidOfloxacinisoniazidinterleukin-6TuberculosisSolvent evaporationSPIONsMinimum inhibitory concentrationSpray-dryingSupercritical carbon dioxideRifabutinRifampicinRifapentineMultidrug-resistant tuberculosisSimulated lung fluidTNF-αSupercritical anti-solvent processPhosphate buffered salineMass median aerodynamic diameterLysineExtracellular matrixMannitolAlveolar macrophagesMycobacterium tuberculosisManPolymeric materialsSuperparamagnetic iron oxide nanoparticlesMagnetic nanoparticlesPASNitric oxideDrug targetingHydroxy propyl methyl cellulosePyrazinamidepoly(lactide-co-glycolide)Poly-caprolactoneDry powdersDry powder inhalersCapreomycinFine particle fractionChitosan
Related Topics
Physical Sciences and Engineering
Materials Science
Biomaterials
Authors
Margarida S. Miranda, Márcia T. Rodrigues, Rui M.A. Domingues, EgÃdio Torrado, Rui L. Reis, Jorge Pedrosa, Manuela E. Gomes,