Systemic L-buthionine-S-R-sulfoximine administration modulates glutathione homeostasis via NGF/TrkA and mTOR signaling in the cerebellum

Article ID	Journal	Published Year	Pages	File Type
11008694	Neurochemistry International	2018	34 Pages	PDF

Keywords

BSO ERK GSSG DAPI EAAC1 EAAT3 NGF NeuN GCL mGluR PI3K LAT1 mTORC1 4F2hc S6K xCT tropomyosin receptor kinase A GSH peroxidase GSH reductase GSH S-transferase OPA mTOR GSH GST GPX NAC L-type amino acid transporter 1 PIKK mTOR complex 1 N-acetylcysteine o-Phthalaldehyde PKB/AKT ROS Hydrogen peroxide excitatory amino acid carrier 1 excitatory amino acid transporter 3 intraperitoneal CNS diethylenetriamine penta-acetic acid Redox BBB central nervous system neuronal growth factor phosphoinositide 3-kinase γ-glutamylcysteine ligase Blood-brain barrier Cerebellum H2O2 Protein kinase B/Akt extracellular signal-regulated kinases Glutathione Reactive oxygen species Metabotropic glutamate receptors

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Systemic L-buthionine-S-R-sulfoximine administration modulates glutathione homeostasis via NGF/TrkA and mTOR signaling in the cerebellum

Authors

Carla Garza-Lombó, Pavel Petrosyan, Miguel Tapia-RodrÃguez, Cesar Valdovinos-Flores, MarÃa E. Gonsebatt,