| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 11014008 | Translational Research | 2018 | 27 Pages |
Abstract
Liquid biopsies examine tumor cells or tumor genomic content in circulating fluids. In advanced prostate cancer which metastasizes frequently to the bone, it is difficult to evaluate underlying and evolving genomic heterogeneity of skeletal metastases for effecting clinical care for which reason liquid biopsies offer an alternate approach. In this review, we will summarize the current state of a wide variety of liquid biopsy-based biomarker assays currently being investigated and developed for managing prostate cancer. We will also highlight technical and clinical challenges and opportunities for translating liquid biopsies into clinical applications.
Keywords
deoxyribo nucleic acidCRPCEpCAMDREmCRPCPARPNHTRAFqRT-PCRCtDNANGSPSALBDmiRNAsCTCCNVmRNAsDNAPCAAbiraterone acetateProstate specific antigenRNAribonucleic acidEnzalutamidecopy number variationNext generation sequencingCirculating tumor cellsligand-binding domainmessenger ribonucleic acidProstate cancerMetastatic castration resistant prostate cancerCastration resistant prostate cancerrapidly accelerated fibrosarcomadigital rectal examinationepithelial cell adhesion moleculeBenign prostatic hyperplasiaBPHQuantitative reverse transcriptase polymerase chain reactionpoly ADP ribose polymeraseAndrogen Receptor
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Authors
Irbaz Bin Riaz, Liang Wang, Manish Kohli,