Auto-injecteurs d'adrénaline : quel dosage ? Position du groupe de travail anaphylaxie sous l'égide de la Société française d'allergologie

Intramuscular adrenaline is the first-line treatment for anaphylaxis. Adrenaline auto-injectors allow injection under conditions of optimal efficacy and safety, but commercially available formulations are restricted to a dose range of 0.15 and 0.50 mg per injection. All the international anaphylaxis guidelines recommend the administration of intramuscular adrenaline at a dose of 0.01 mg/Kg of body weight, with a maximum dose of 0.5 mg per injection, despite the lack of evidence-based data. This position statement, prepared by the Anaphylaxis working group of the French Allergology Society, attempts to analyse current data regarding the use of adrenaline auto-injectors as treatment of anaphylaxis with, in particular, emphasis on the dosage issue.