Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11015343 | Molecular and Cellular Neuroscience | 2018 | 20 Pages |
Abstract
These data show that CAW can improve many facets of Aβ-related cognitive impairment in 5xFAD mice. Oral treatment with CAW also attenuates hippocampal mitochondrial dysfunction in these animals. Because mitochondrial dysfunction and oxidative stress accompany cognitive impairment in many pathological conditions beyond Alzheimer's disease, this suggests potentially broad therapeutic utility of CAW.
Keywords
MWMMT-CO1MT-ATP6mt-ND1OCRGCLCNQO1OLMHMOX1WCSTPSD95RCRFCCPqPCRTBSGAPDHCFRNrf2ADPAββ-AmyloidATPadenosine diphosphateAntioxidantBeta amyloidAlzheimer's diseaseTris buffered salineWisconsin Card Sorting TestObject location memoryelectron transport chainMitochondrial functionMorris water mazeOxygen consumption raterespiratory control ratiowild typeheme oxygenase 1ETcquantitative polymerase chain reactionpost-synaptic density protein 95executive functioncarbonyl cyanide p-(trifluoromethoxy)phenylhydrazone
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Authors
Nora E. Gray, Jonathan A. Zweig, Maya Caruso, Jennifer Y. Zhu, Kirsten M. Wright, Joseph F. Quinn, Amala Soumyanath,