Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11018310 | American Journal of Obstetrics and Gynecology | 2018 | 27 Pages |
Abstract
These findings demonstrate that postnatal effects of infection occurring at single time points continue to be detrimental to offspring in the postnatal period in a subset of littermates and subject to a window of gestational susceptibility coinciding with placentation. This model recapitulates frequently encountered clinical scenarios in nonendemic regions, including the majority of the United States, where travel-related exposure occurs in short and well-defined windows of gestation. Our low rate of infection and relatively rare evidence of congenital Zika syndrome parallels human population-based data.
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Authors
Gregory C. MD, Maxim D. PhD, Stephanie W. PhD, Angela M. Major, Rodion MS, Rebecca BS, Alton G. DVM, Kristy O. DVM, PhD, Melissa A. PhD, Kjersti M. MD, PhD,