Cardiorespiratory fitness and cognitive processing speed in multiple sclerosis: The possible roles of psychological symptoms

The present pattern of results suggests that aerobic exercise training (via improving cardiorespiratory fitness) might improve cognitive processing speed independent of the influence of depression, pain, and fatigue. Such results further suggest that having elevated depressive symptoms or severe MS-related fatigue might not affect aerobic exercise training-related changes in cognitive processing speed, and that psychological symptoms might not distort the association between aerobic exercise training and changes in cognitive processing speed.