Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11019135 | Journal of Clinical & Translational Endocrinology | 2018 | 7 Pages |
Abstract
Central hypothyroidism (CH) occurs approximately in 1:50,000, and therefore is expected to be one thousand times rarer compared with primary hypothyroidism. Despite its rarity in the general population, it is much more common in certain disorders, in which it is frequently associated with other pituitary hormone deficiencies. The aim of this paper is to provide an updated review on the frequency of congenital CH, which is <1:50,000, and on its etiology, disregarding CH caused by other genetic defects, such as mutations of transcription factors involved in pituitary organogenesis or mutations of the genes encoding TRH or TRH receptor.
Keywords
SWStotal triiodothyroninefT3tT4PC1/3ALGSTT3Dandy-Walker syndromeFT4ACTHTSHROHHADDWSSCDPWSTSH-releasing hormoneHCGtrhthyrotropinFree thyroxineSepto-optic dysplasiaSODPrader-Willi syndromeSturge-Weber syndromeFree triiodothyronineTotal thyroxineadrenocorticotropin hormoneGrowth hormoneHypopituitarismSickle cell anemiacongenital hypothyroidismCentral hypothyroidismhuman chorionic gonadotropin
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Authors
Salvatore Benvenga, Marianne Klose, Roberto Vita, Ulla Feldt-Rasmussen,