Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11020649 | Biosensors and Bioelectronics | 2019 | 25 Pages |
Abstract
A simple, facile and sensitive photoelectrochemical (PEC) bioassay protocol for metronidazole (MNZ) detection in common oral medicine samples has been proposed under visible-light irradiation, where novel hierarchical coral-like g-C3N4 nanoarchitectures (cg-C3N4) have been first explored as PEC sensing platform. Featured with the unique nanostructures (e.g., interlaced porous network architecture, and open boundaries), the as-formed cg-C3N4 nanoarchitectures not only efficiently inhibit the recombination of photogenerated electron-hole but also enable the immobilization of capture antibodies as well as the antibody-antigen binding efficiency fluently, thus amplifying the photocurrent response. This newly constructed PEC immunoassay displays excellent performance for MNZ determination with high sensitivity and selectivity. Under the optimal condition, this bioassay protocol exhibits a linear range of 0.01-100â¯ÂµM with a detection limit of 0.005â¯ÂµM at signal to noise ratio of 3. The resulting PEC immunoassay has been proved to be applicable for sensing MNZ in common oral medicine samples.
Related Topics
Physical Sciences and Engineering
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Authors
Xin Li, Yijin Yuan, Xinmeng Pan, Lizhi Zhang, Jingming Gong,