| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 11022634 | Metabolism | 2018 | 32 Pages |
Abstract
Five novel GCK mutations have been identified in Chinese MODY. The defects in enzymatic activity and protein stability, together with alteration of GKRP binding on GCK mutants may synergistically contribute to the development of MODY2 hyperglycaemia. No treatment should be prescribed to MODY2 patients when insulin resistance is not present.
Keywords
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Endocrinology
Authors
Limei Liu, Yanjun Liu, Xiaoxu Ge, Xipeng Liu, Chen Chen, Yanzhong Wang, Ming Li, Jun Yin, Juan Zhang, Yating Chen, Rong Zhang, Yanyan Jiang, Weijing Zhao, Di Yang, Taishan Zheng, Ming Lu, Langen Zhuang, Meisheng Jiang,