| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 11025276 | European Journal of Radiology | 2018 | 25 Pages |
Abstract
The diffusion changes (FA and RD) measured in lesioned CP are probably directly related to the presence of inflammatory and/or demyelinating lesions. In contrast, the microstructural alterations reflected by AD increase in non-lesioned CP may result either from remote effects of cerebral white matter injury (diaschisis) or primary axonal degeneration, that are associated with cognitive, sensory and motor impairments of MS patients.
Keywords
ICBMRRMsPPMSFSLSPMSEDSSNAWM9-HPTPASATDTITBSSMSFCSCPICPMCPaxial diffusivityrelapsing remitting multiple sclerosis9-hole peg testtract-based spatial statisticssuperior cerebellar peduncleMRIradial diffusivityPaced Auditory Serial Addition Testdiffusion tensor imagingDiffusion tensor imaging (DTI)Magnetic resonance imaginginferior cerebellar peduncleMiddle cerebellar pedunclecerebellar peduncleGray matternormal appearing white mattercerebro-spinal fluidCSFmean diffusivityDisease durationExpanded Disability Status ScaleMultiple sclerosis (MS)secondary progressive multiple sclerosisprimary progressive multiple sclerosisMultiple sclerosisfractional anisotropyMultiple sclerosis functional compositehealthy controls
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Authors
Salem Hannoun, Gabriel Kocevar, Françoise Durand-Dubief, Claudio Stamile, Amal Naji, Francois Cotton, Michele Cavallari, Charles R.G. Guttmann, Dominique Sappey-Marinier,