Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11025485 | World Neurosurgery | 2018 | 19 Pages |
Abstract
Since Li-Fraumeni syndrome is a genetic disease that is caused by mutation of the tumor suppression gene TP53, patients should generally not be treated with radiotherapy or alkylating agents that induce deoxyribonucleic acid damage. However, if the prognostic benefit of postoperative adjuvant therapies is thought to surpass the risk of long-term secondary cancer, it is appropriate to consider these therapies after consultation with the patient and family. Postoperative treatment protocols are controversial, and their role should be further explored in cases of Li-Fraumeni syndrome complicated with malignant gliomas.
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Authors
Tomohiro Hosoya, Atsushi Kambe, Yoko Nishimura, Makoto Sakamoto, Yoshihiro Maegaki, Masamichi Kurosaki,