Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11025540 | NeuroImage | 2019 | 15 Pages |
Abstract
We have successfully created a small bispecific antibody-based radioligand capable of crossing the BBB, subsequently binding to and visualizing intrabrain Aβ in vivo. The radioligand displayed better sensitivity compared with [11C]PIB, and brain concentrations correlated with soluble neurotoxic Aβ aggregates.
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Authors
Xiaotian T. Fang, Greta Hultqvist, Silvio R. Meier, Gunnar Antoni, Dag Sehlin, Stina Syvänen,