Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11025675 | Reproductive Toxicology | 2018 | 24 Pages |
Abstract
The aim of this study was to determine serum bisphenol A (BPA) concentrations using high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) in women with polycystic ovary syndrome (PCOS) (nâ=â106, age range 18-40 yrs) and to evaluate its potential impact on their hormonal and metabolic profile. The control group consisted of age- and BMI-matched 80 eumenorrheic women with no clinical or biochemical hyperandrogenism. Our results showed that women with PCOS had significantly higher serum BPA concentrations than healthy controls (geometric mean and [95% CI]: 0.202âng/mL [0.150; 0.255] vs. 0.154âng/mL [0.106; 0.201], Pâ=â0.035), which correlated positively with serum total testosterone (TST) (R=0.285, Pâ=â0.004) and the free androgen index (FAI) (Râ=â0.196, Pâ=â0.049). There were no significant correlations between serum BPA and BMI, waist circumference, serum glucose, insulin and lipids. These results point to the potential role of BPA in the pathogenesis of the ovarian hyperandrogenism in women with PCOS.
Keywords
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Authors
Aleksandra Konieczna, Dominik RachoÅ, Katarzyna Owczarek, PaweÅ Kubica, Agnieszka Kowalewska, BÅażej KudÅak, Andrzej Wasik, Jacek NamieÅnik,