Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11025733 | Biomedicine & Pharmacotherapy | 2018 | 9 Pages |
Abstract
microRNAs are being investigated as promising therapeutic targets and biomarkers for different disease conditions. miRNAs serve as essential regulators of cell differentiation, proliferation and survival. The involvement of miRNAs in the functioning and regulation of the skin cells and skin diseases is a rapidly advancing area in dermatological research. miRNAs have been identified to play a key role in the pathogenesis, diagnosis, and treatment of the skin diseases. Skin is one of the largest organs of the body, primarily functioning as the first line of defence against external insults including bacteria, virus and other pathogens. Various miRNAs have been identified to demonstrate significant effects in various skin inflammatory conditions such as wounds, cancer, psoriasis, scleroderma, dermatomyositis. The current review explores the possible roles of the miRNAs in skin disorders and reports relating to the clinical trials involving skin diseases and miRNAs. The review has also compiled the information of the databases available, which correlates the miRNAs with different diseases and give details about targeting interactions of miRNA.
Keywords
ECMprecursor miRNARUNX3PDGFTGFpri-miRNAMIRFGFPrimary miRNAskin disordersSclerodermaWound Healingtransforming growth factorsingle-strandedRISCdermatomyositisDouble strandedmicroRNAsplatelet-derived growth factorfibroblast growth factorRunt-related transcription factor 3RNA Induced Silencing ComplexMicroRNApolymerase chain reactionPCRPsoriasis
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Authors
Gautam Singhvi, Prachi Manchanda, Vamshi Krishna Rapalli, Sunil Kumar Dubey, Gaurav Gupta, Kamal Dua,