| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 11025937 | Cancer Letters | 2018 | 30 Pages |
Abstract
Our study reveals a role of SLC25A10 in supporting both, redox- and energy-homeostasis, ensuring radioresistance of cancer cells with tolerance to chronic-cycling hypoxia thereby proposing a novel strategy to overcome a mechanism of hypoxia-induced therapy resistance with potential clinical relevance regarding decreased patient survival.
Keywords
OCRROXPFAHIF1qRT-PCRBMAeIF2αGSHTCACTRLPSAb2mMrOSDABGOT1Ubiquitin C-terminal hydrolase-L1UCHL1H&EHCCROSβ2-microglobulinImmunohistochemistryIHCMetabolic reprogrammingionizing radiationfold changeGEEGrayperdihydroethidiumdiaminobenzidineRadiotherapyNSCLCNon-small cell lung cancerAntioxidant capacityeukaryotic initiation factor 2αhypoxia-inducible factor 1phosphoenolpyruvate carboxykinasePhenylsuccinateRadiation resistancenot significantOxygen consumption ratehaematoxylin and eosinDHEETcquantitative real-time PCRparaformaldehydePropidium iodidePERKtricarboxylic acid cycleHepatocellular carcinomaControlGlutathioneGlutathione ethyl estermitochondrial reactive oxygen speciesReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Julian Hlouschek, Violetta Ritter, Florian Wirsdörfer, Diana Klein, Verena Jendrossek, Johann Matschke,