Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11026272 | Applied Radiation and Isotopes | 2018 | 24 Pages |
Abstract
In this study, internalization of positively charged chitosan-coated nanoparticles (198AuNPs@chitosan) on MCF-7 cells was investigated by γ-ray spectroscopy and then statistically compared to that of 198Au and negatively charged citrate-stabilized nanoparticles (198AuNPs). Sub-50â¯nm 198AuNPs@chitosan had a higher internalization compared to 198Au and 198AuNPs (pâ¯<â¯0.05). More cellular uptake of 198AuNP@chitosan means a higher dose of radioactivity to the tumor cells which, in turn, more effective treatment of the cancer.
Related Topics
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Authors
Mohammad Reza Aboudzadeh Rovais, Behrouz Alirezapour, Mohammad Esmaeil Moassesi, Mojtaba Amiri, Fatemeh Bolouri Novin, Ehsan Maadi,