Label-free tissue proteomics can classify oral squamous cell carcinoma from healthy tissue in a stage-specific manner

Article ID	Journal	Published Year	Pages	File Type
11029138	Oral Oncology	2018	10 Pages	PDF

Abstract

We found a set of proteins reliably separating OSCC tumour from healthy tissue, and multiple proteins differing between stage I and stage IVa OSCC. These potential biomarkers can be studied and validated in larger cohorts.

Keywords

PMCA1 Tissue proteomics HCA BCA IPA PABPN1 IP3R PSAP S100A7 NF-κB AUROC TNM NDRG1 Prosaposin CAIX STMN1 OPLS-DA HNSCC PPI tPA CA1 DTT TMA IAA OSCC DSS H&E MAPK PCA EDTA Stathmin 1 IHC Immunohistochemistry disease-specific survival SCLC bicinchoninic acid hierarchical clustering analysis Ingenuity Pathway Analysis Principal component analysis Protein-protein interactions dithiothreitol Tongue cancer Small cell lung cancer Head and neck cancer Mass spectrometry nuclear factor-κB area under the receiver operating characteristic curve Tissue microarray haematoxylin and eosin mitogen activated protein kinase orthogonal projections to latent structures discriminant analysis oral squamous cell carcinoma Head and neck squamous cell carcinoma Keratin Carbonic anhydrase IX Krt inositol triphosphate receptor iodoacetamide

Related Topics

Health Sciences Medicine and Dentistry Dentistry, Oral Surgery and Medicine

Label-free tissue proteomics can classify oral squamous cell carcinoma from healthy tissue in a stage-specific manner

Authors

Amy Dickinson, Mayank Saraswat, Antti Mäkitie, Robert Silén, Jaana Hagström, Caj Haglund, Sakari Joenväärä, Suvi Silén,