Long-term tolerability, safety and efficacy of adjunctive perampanel in the open-label, dose-ascending Study 231 and extension Study 233 in Japanese patients with epilepsy

Article ID	Journal	Published Year	Pages	File Type
11031646	Seizure	2018	7 Pages	PDF

Abstract

Adjunctive perampanel demonstrated a favourable safety profile and long-term tolerability in Japanese patients with refractory POS for â¤316 weeks.

Keywords

EIAED AED Cbz enzyme-inducing antiepileptic drug CyP PHT AMPA LOCF TEAE α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid standard deviation Epilepsy antiepileptic drug antiepileptic drugs Cytochrome P450 adverse event treatment-emergent adverse event Pharmacokinetics Phenobarbital Phenytoin last observation carried forward Perampanel pos carbamazepine AMPA receptor

Related Topics

Life Sciences Neuroscience Behavioral Neuroscience

Long-term tolerability, safety and efficacy of adjunctive perampanel in the open-label, dose-ascending Study 231 and extension Study 233 in Japanese patients with epilepsy

Authors

Naotaka Usui, Naoki Akamatsu, Nobukazu Nakasato, Akihiro Ohnishi, Sunao Kaneko, Hidetaka Hiramatsu, Kazunori Saeki, Hideaki Miyagishi, Yushi Inoue,