Article ID Journal Published Year Pages File Type
11032199 Polymer Testing 2018 40 Pages PDF
Abstract
The resulting gelatins were structurally characterized by optical microscopy, differential scanning calorimetry (DSC), as well as by X-ray diffraction (XRD) and nuclearmagnetic resonance (NMR) spectroscopies. According to optical micrographs, DSC analysis, and XRD spectra, GGSGs are semi-crystalline polymers. Antioxidant activities of GGSGs were evaluated by five different methods in-vitro. GGSGs acted as a strong free-radical scavengers and they effectively protected skin genomic DNA against hydroxyl radical-induced oxidative damage. In addition, the wound healing efficiency of the GGSGs was assessed on circular excision wound rat model. GGSGs exhibited remarkable wound healing properties with 100% reduction of the wound area within 14 days. Histological examination also demonstrated a fully re-epithelialized wound with epidermal regeneration. These evidences depicted that GGSGs can be an ideal biomaterial for enhanced wound-healing effect presumably achieved through their antioxidant properties.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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