| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 11032234 | Journal of Inorganic Biochemistry | 2018 | 10 Pages |
Abstract
This work presents a novel click-based method to enrich Pt(II)-bound biomolecules. Pt(II)-bound DNA and proteins are readily isolated using an oligonucleotide hybridization strategy. Interestingly, Pt(II)-dependent and click-independent crosslinking of a DNA oligonucleotide to serum albumin was observed, and DNA crosslinked to protein is dramatically protected from serum nucleases.246
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Rachael M. Cunningham, Anna M. Hickey, Jesse W. Wilson, Kory J.I. Plakos, Victoria J. DeRose,