Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
11032242 | Journal of Inorganic Biochemistry | 2018 | 7 Pages |
Abstract
Amino-decorated nonporous silica nanoparticles were further coated with alginic acid to produce a potential biocompatible delivery system for Pt(IV) antitumor prodrug (OCâ6â44)âacetato(βâalaninato)diamminedichloridoplatinum(IV), through the formation of amide bonds. The conjugate was more active than both cisplatin and the Pt(IV) precursor, due to its more efficient cell uptake.112
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Inorganic Chemistry
Authors
Mauro Ravera, Elisabetta Gabano, Diego Bonzani, Ilaria Zanellato, Aldo Arrais, Simone Cantamessa, Marco Biggiogera, Domenico Osella,