The expression of adenosine receptors changes throughout light induced retinal degeneration in the rat

Article ID	Journal	Published Year	Pages	File Type
11033440	Neuroscience Letters	2018	27 Pages	PDF

Abstract

The observed up-regulation of A1R after 1 day of CI, corresponds with the peak of oxidative stress; while the rise of A2aR at day 2 of CI, coincides with the massive apoptosis of photoreceptors. We postulate that an early modulation of adenosine receptors could delay or prevent the degeneration of photoreceptors.

Keywords

A2AR AMD pKa IL-1β GCL NMDA GDNF N-methyl-d-aspartate ISH RPE IPL INL ONL A1R SFK IL-2 OPL NIH Wnt NFL Retinitis pigmentosa light-induced retinal degeneration A3R INF-γ Trk-B A2BR TNF nuclear factor kappa-light-chain enhancer of activated B cells Src family tyrosine kinase NF-κB DAB qRT-PCR RT-PCR IL-6 CTL CPA RGC mRNA BDNF In situ hybridization Adenosine Adenosine Triphosphate ATP gamma-aminobutyric acid retinal pigment epithelium immunoreactive IHC Immunohistochemistry interferon-γ interleukin-6 Interleukin-1β Interleukin-2 Tyrosine kinase B CNS diaminobenzidine messenger ribonucleic acid wingless-related integration site retinal ganglion cell age-related macular degeneration central nervous system Retina Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Glial cell line-derived neurotrophic factor Brain-derived neurotrophic factor tumor necrosis factor Photoreceptor outer plexiform layer outer nuclear layer inner plexiform layer inner nuclear layer ganglion cell layer Nerve fiber layer National Institutes of Health Watt quantitative reverse transcription polymerase chain reaction reverse transcription polymerase chain reaction Western blot VOLT protein kinase A optical density Control GABA