The relationship between DNA repair genes (XPA, XPF, XPG) polymorphism and the risk of preeclampsia in Chinese Han Women

Our study aimed to investigate the association between polymorphism of three core genes belonging to NER pathway and preeclampsia (PE) risk in Chinese Han Women. The DNA used in our experiment was extracted from 1004 cases and 1274 normal pregnant women. All single nucleotide polymorphisms (SNPs) were analyzed with TaqMan allelic discrimination real-time PCR. Our findings showed the genotype and allele frequency of XPA rs1800975, XPF rs1799801, XPG rs17655 in case group has no significant differences compared with control group (all P > 0.05). However, we found the genotype of rs1799801 in the control group was significantly different from severe PE group in cases (P < 0.05). Moreover, the genotype frequency of rs1800975 and rs1799801in the early-onset PE were significantly different from control group (all P < 0.05). These results indicated that the polymorphism of the three SNPs had no significant correlation with risk of PE as a whole. However, we found XPA rs1800975 played a role in the development of early-onset PE, and XPF rs1799801 was associated with severe PE and early-onset PE. So we may need to continue to increase the sample size to clarify their relationship.