Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1144785 | Journal of the Korean Statistical Society | 2013 | 8 Pages |
Abstract
For an SNP (single-nucleotide polymorphism) sampled from several ethnic populations with different allele frequencies, verifying the homogeneity of Hardy–Weinberg equilibrium or disequilibrium across strata is a critical factor in measuring the quality of the SNP. We obtain a simple unified method that can be applied directly to test the homogeneity of Hardy–Weinberg equilibrium or disequilibrium across strata. The deviation of each ethnic population from homogeneity is measured via a new exact test that depends on a common homogeneity coefficient. Tippett’s minimum pp-value method is then used to test for homogeneity across strata.
Related Topics
Physical Sciences and Engineering
Mathematics
Statistics and Probability
Authors
Jeongjin Kim, Hye Soo Kwon, Mun S. Son, Tae Young Yang,