Sensitivity analysis of longitudinal data with intermittent missing values

Several models for longitudinal data with nonrandom missingness are available. The selection model of Diggle and Kenward is one of these models. It has been mentioned by many authors that this model depends on untested modelling assumptions, such as the response distribution, from the observed data. So, a sensitivity analysis of the study’s conclusions for such assumptions is needed. The stochastic EM algorithm is proposed and developed to handle continuous longitudinal data with nonrandom intermittent missing values when the responses have non-normal distribution. This is a step in investigating the sensitivity of the parameter estimates to the change of the response distribution. The proposed technique is applied to real data from the International Breast Cancer Study Group.