Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1155269 | Statistics & Probability Letters | 2007 | 8 Pages |
Abstract
Based on reinforced urn process introduced by Muliere et al. [2000. Urn schemes and reinforced random walks. Stochastic Process. Appl. 88(1), 59–78] we propose a Bayesian nonparametric approach to analyse a design determining the maximum tolerated dose (MTD) in Phase I clinical trials for new drug development when intrapatient dose escalation is allowed. A predictive distribution of MTD is obtained and its point estimation may consist in the corresponding expected value.
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Physical Sciences and Engineering
Mathematics
Statistics and Probability
Authors
Maura Mezzetti, Pietro Muliere, Paolo Bulla,