Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1176427 | Analytical Biochemistry | 2013 | 5 Pages |
Abstract
A novel potentiometric sensor with high selectivity and sensitivity has been developed for the determination of heparin, based on the modification of heparin-imprinted polymer film onto a glassy carbon. The performance of the developed heparin sensor was evaluated, and the results indicated that a sensitive potentiometric sensor could be fabricated. The obtained heparin sensor shows high-selectivity monitoring of heparin, shorter response time (<4 min), wider linear range (0.003–0.7 μM), lower detection limit (0.001 μM), and satisfactory long-term stability (>2 months). The potentiometric sensor was successfully applied to the determination of heparin in heparin sodium injection with recoveries between 97.1% and 110.0%.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Lifeng Li, Yizeng Liang, Youcai Liu,