Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1177987 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2009 | 10 Pages |
Abstract
Multidrug transporters are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell. Through this function, they render cells resistant to multiple drugs. These transporters are found in many different families of transport proteins, of which the largest is the major facilitator superfamily. Multidrug transporters from this family are highly represented in bacteria and studies of them have provided important insight into the mechanism underlying multidrug transport. This review summarizes the work carried out on these interesting proteins and underscores the differences and similarities to other transport systems.
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Authors
Nir Fluman, Eitan Bibi,