Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1179047 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2008 | 8 Pages |
Abstract
This article reports on the current status of the research on blood substitutes with particular attention on hemoglobin-based oxygen carriers (HBOCs). Insights on the physiological role of hemoglobin are reported in the view of the development of both acellular and cellular hemoglobin-based oxygen carriers. Attention is then focused on biocompatible polymeric materials that find application as matrices for cellular based HBOCs and on the strategies employed to avoid methemoglobin formation. Results are reported regarding the use of bioerodible polymeric matrices based on hemiesters of alternating copolymer (maleic anhydride-co-butyl vinyl ether) for the preparation of hemoglobin loaded nanoparticles.
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Authors
Anna Maria Piras, Alberto Dessy, Federica Chiellini, Emo Chiellini, Claudio Farina, Massimiliano Ramelli, Elena Della Valle,