Article ID Journal Published Year Pages File Type
1181508 Chemometrics and Intelligent Laboratory Systems 2009 14 Pages PDF
Abstract
Based on a recently developed spot segmentation method, we here present a new approach to modelling of individual spots in digital images, e.g. images of DNA microarrays. From the model parameter estimates and residuals we have developed an expedient approach to automatic quality assessment and identification of corrupted spots. The suggested approach to quality control is shown to give a statistically significant decrease of the variance in gene expression log-ratio estimates for three different DNA microarray datasets.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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