Progress of Interdigitated Array Microelectrodes Based Impedance Immunosensor

Interdigitated array microelectrodes (IDAMs) possess promising advantages in terms of low detection limit, high sensitivity, and increased signal-to-noise ratio, which have hence received enormous attention in the area of analytical chemistry. According to the impedance signal induced by immune reaction of the antigen and the specific antibody on the surface of microelectrodes, IDAMs-based impedance immunosensors can specifically detect a target analyte in samples. This review introduces the characteristics, materials, and design parameters of IDAMs; discusses the principle and equivalent circuits of an impedance immunosensor; and summarizes their applications in food safety and clinical diagnosis. Additionally, the shortcomings of current research and the future trends are also discussed.