Article ID Journal Published Year Pages File Type
1181927 Chinese Journal of Analytical Chemistry 2014 7 Pages PDF
Abstract

Nanocapsules is widely used in the biomedical field because of its unique features. A new nanocapsule was prepared by using gold cage as the core, anticancer drug doxorubicin hydrochloride (DOX) as the internal filler, and functionalized DNA nanomaterials as the shell. The mouth of the cage was blocked by the functionalized DNA nanomaterials. The nanocapsule can be used for the cell detection and drug delivery. The target cells (Ramos cells) can be detected by fluorescence microscope when the drug that can act on target cells and lead to cell death was released. The nanocapsule provides a new approach for the diagnosis and treatment of tumor cells.

Graphical abstractA new nanocapsule was prepared by using gold cage as the core, anticancer drug doxorubicin hydrochloride (DOX) as the internal filler, and functionalized DNA nanomaterials as the shell. The mouth of the cage was blocked by the functionalized DNA nanomaterials. The nanocapsule can be used for the cell detection and drug delivery. The target cells (Ramos cells) can be detected by fluorescence microscope when the drug that can act on target cells and lead to cell death was released. The nanocapsule provides a new approach for the diagnosis and treatment of tumor cells.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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