Progress in Research Methods for Protein Palmitoylation

Protein palmitoylation, as one of the most important lipid post-translational modifications, plays a key role in different cellular functions such as signal transduction, metabolism, apoptosis, and so on. Disorders of protein palmitoylation will lead to many human diseases, including cancer. Therefore, qualitative and quantitative analysis of protein palmitoylation is very important for underlying its biological functions. Here, the technologies and methods for palmitoylation in recent years were reviewed. Their advantages/disadvantages and future trend were also discussed.

Graphical abstractPalmitoylation, which is a reversible and dynamic lipid post-translational modification, plays critical roles in many cellular functions and in disease. Qualitative and quantitative analysis of protein palmitoylation can help to elucidate their underlying mechanism and biological function. Here, the techniques for palmitoylation in recent years were reviewed.Figure optionsDownload full-size imageDownload as PowerPoint slide