Progress on Click Chemistry and Its Application in Chemical Sensors

In recent years, in the field of chemical sensors, the sensors with high selectivity, stability and repeatability are becoming increasingly urgent. Click chemistry provides a new efficient and convenient way for these researches, which have become a hot field. In this review, the concept and classification of click chemistry and the working mechanisms in chemical sensors and biosensors, as well as some recent developments were introduced in detail. The prospect of this application was also discussed.

Click chemistry provides a new efficient and convenient way for construction of chemical sensors and biosensors. For example, azides and terminal alkynes were converted into 1,4-disubstituted 1,2,3-triazoles through a highly efficient and regioselective Cu+-catalyzed process in preparing a solid state ECL sensor for tri-n-propylamine determination.Figure optionsDownload full-size imageDownload as PowerPoint slide