A Wearable Wireless Electrochemical Instrument Used for In-vivo Neurotransmitter Detection

A wireless electrochemical recording device was developed for the neurotransmitters real-time detection with a low-power microcontroller MSP430 as main control unit, including current detection module, waveform generator module and data transceiver module. This device has a small size (2.3 cm × 1.8 cm × 0.6 cm) and low power consumption. In the experiment, firmware program was designed based on uC/OS operating system and online display and analysis of recording data were carried out by the proposed system combined with the PC software. The system implemented two electroanalytical methods, fast-scan cyclic voltammetry (FSCV) and fixed-potential amperometry, to measure neurotransmitter concentrations at microelectrode. By using fast-scan cyclic voltammetry method, a linear relationship (R = 0.99) between the concentration of dopamine and response current was acquired in the concentration range of 0.5 × 10−6−7.0 × 10−5 M. In the in-vivo experiments, the electrically evoked dopamine was recorded in the caudate-putamen area of brain in rats. The experimental results show that the system has high detection accuracy, realizing the qualitative and quantitative analysis of brain neurotransmitter.

Wireless electrochemical recording device was developed for the neurotransmitters real-time detection with a low-power microcontroller MSP430 as main control unit, including current detection module, waveform generator module and data transceiver module. In addition, two electrode setups, counter electrode and working electrode, were adopted to realize electrochemical detection and the date were digitized and transmitted wirelessly to computer for further processing.Figure optionsDownload full-size imageDownload as PowerPoint slide